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Description for Protein GPT

glutamic-pyruvate transaminase (alanine aminotransferase)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.6.1.2
KEGG - Orthology:
K00814
KEGG - Pathway(s):
hsa00250; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GPT1; Alanine aminotransferase 1; AAT1; ALT1; Alanine aminotransferase; EC 2.6.1.2
Approved Symbol:
GPT
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Alanine(db);
  • L-Glutamic Acid(db);
  • Phenelzine(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

  • Glutamic-pyruvate transaminase, polymorphism of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00689 Entrez Gene ID: 2875 OMIM ID: 138200 Swissprot Accession: P24298;