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Description for Protein GPS1

G protein pathway suppressor 1
20 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 5)
Summary:
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PINT: motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12175
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CSN1; COP9 signalosome complex subunit 1; COPS1; MGC71287; FUS6/COP11 homolog; SGN1; JAB1-containing signalosome subunit 1; GPS1 protein; MFH protein; G protein pathway suppressor 1 isoform 2; G protein pathway suppressor 1 isoform 1
    Approved Symbol:
    GPS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15991 Entrez Gene ID: 2873 OMIM ID: 601934 Swissprot Accession: Q13098;