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Description for Protein GRK6

G protein-coupled receptor kinase 6
17 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 5)
Summary:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • RGS: Regulator of G protein signalling domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.16
    KEGG - Orthology:
    K08291
    KEGG - Pathway(s):
    hsa04062; hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FLJ32135; GPRK6; G protein-coupled receptor kinase 6 isoform B; G protein-coupled receptor kinase 6 isoform A; G protein-coupled receptor kinase 6 isoform C
    Approved Symbol:
    GRK6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 6; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02925 Entrez Gene ID: 2870 OMIM ID: 600869 Swissprot Accession: P43250;