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Description for Protein ANG

angiogenin, ribonuclease, RNase A family, 5
7 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.27.-
    KEGG - Orthology:
    K01172
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Angiogenin; Ribonuclease A family, 5; RNASE5
    Approved Symbol:
    ANG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Citric Acid(db);
  • Pyroglutamic Acid(db);
  • Pyrophosphate 2-(db)

    Associated Genetic Diseases:

  • Amyotrophic lateral sclerosis, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00105 Entrez Gene ID: 283 OMIM ID: 105850 Swissprot Accession: Q53X86; P03950;