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Description for Protein GPI

glucose-6-phosphate isomerase
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 4; secretome: 1)
Summary:
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.3.1.9
KEGG - Orthology:
K01810
KEGG - Pathway(s):
hsa00010; hsa00030; hsa00500; hsa00520; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glucose 6-phosphate isomerase; neuroleukin; Autocrine motility factor; Sperm antigen 36; Phosphoglucose isomerase; Hexosephosphate isomerase; Phosphosaccharomutase; PHI; PGI; AMF; NLK
Approved Symbol:
GPI
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-Phospho-D-Arabinohydroxamic Acid(db);
  • 5-Phosphoarabinonic Acid(db);
  • 6-Phosphogluconic Acid(db);
  • Alpha-D-Glucose-6-Phosphate(db);
  • Beta-Mercaptoethanol(db);
  • Erythose-4-Phosphate(db);
  • Fructose-6-Phosphate(db);
  • Glucose-6-Phosphate(db);
  • Sorbitol 6-phosphate(db)

    Associated Genetic Diseases:

  • Hemolytic anemia, chronic, and neurologic deficits, due to GPI deficiency(Pd);
  • Hemolytic anemia, chronic, due to GPI deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01394 Entrez Gene ID: 2821 OMIM ID: 172400 Swissprot Accession: P06744;