Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein GPD2

glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(membrane: 2; microparticles: 2; platelet: 8; undefined: 1)
Summary:
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene. (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.5.3
    KEGG - Orthology:
    K00111
    KEGG - Pathway(s):
    hsa00564
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GPD, mitochondrial; GDH2; EC 1.1.99.5; MGPDH; Glycerol-3-phosphate dehydrogenase 2 (mitochondrial); Mitochondrial glycerophosphate dehydrogenase
    Approved Symbol:
    GPD2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Diabetes mellitus, type II(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00715 Entrez Gene ID: 2820 OMIM ID: 138430 Swissprot Accession: P43304;