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Description for Protein GP9

glycoprotein IX (platelet)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/3)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 7; undefined: 2)
Summary:
This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • LRR: Leucine-rich repeats, outliers
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06263
    KEGG - Pathway(s):
    hsa04512; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glycoprotein IX, platelet; GP IX; CD42a
    Approved Symbol:
    GP9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Quinine(db)

    Associated Genetic Diseases:

  • Bernard-Soulier syndrome, type C(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01432 Entrez Gene ID: 2815 OMIM ID: 173515 Swissprot Accession: P14770;