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Description for Protein GP1BA

glycoprotein Ib (platelet), alpha polypeptide
16 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(alpha granules: 1; membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 3; secretome: 1; undefined: 2)
Summary:
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LRR: Leucine-rich repeats, outliers
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06261
    KEGG - Pathway(s):
    hsa04512; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GP Ib, alpha subunit; Glycocalicin; Platelet glycoprotein Ib alpha polypeptide
    Approved Symbol:
    GP1BA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 8; Platelet phosphorylation sites: 5
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

  • Bernard-Soulier syndrome, type A(Pd);
  • Bernard-Soulier syndrome, type A, autosomal dominant(Pd);
  • Platelet glycoprotein ib polymorphism(Pd);
  • Von Willebrand disease, platelet-type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01976 Entrez Gene ID: 2811 OMIM ID: 606672 Swissprot Accession: A5CKE2; P07359;