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Description for Protein GOT2

glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(microparticles: 1; platelet: 3; secretome: 1)
Summary:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.6.1.1
    KEGG - Orthology:
    K00813
    KEGG - Pathway(s):
    hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glutamate oxaloacetate transaminase-2; Aspartate Aminotransferase 2; mAspAT; EC 2.6.1.1
    Approved Symbol:
    GOT2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate(db);
  • L-Aspartic Acid(db);
  • L-Glutamic Acid(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00684 Entrez Gene ID: 2806 OMIM ID: 138150 Swissprot Accession: P00505;