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Description for Protein GOT1

glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.6.1.1
KEGG - Orthology:
K00813
KEGG - Pathway(s):
hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Aspartate aminotransferase; Transaminase A; Aspartate Aminotransferase 1; EC 2.6.1.1
Approved Symbol:
GOT1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Aspartic Acid(db);
  • L-Cysteine(db);
  • L-Glutamic Acid(db);
  • Maleic Acid(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00687 Entrez Gene ID: 2805 OMIM ID: 138180 Swissprot Accession: P17174;