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Description for Protein GNRHR

gonadotropin-releasing hormone receptor
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04280
    KEGG - Pathway(s):
    hsa04080; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LHRHR; Gonadotropin-releasing hormone receptor isoform 1; Gonadotropin-releasing hormone receptor isoform 2; Luteinizing hormone releasing hormone receptor; LRHR; GRHR; GNRHR1
    Approved Symbol:
    GNRHR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abarelix(db);
  • Buserelin(db);
  • Cetrorelix(db);
  • Danazol(db);
  • Degarelix(db);
  • Gonadorelin(db);
  • Goserelin(db);
  • Leuprolide(db);
  • Nafarelin(db)

    Associated Genetic Diseases:

  • Hypogonadotropic hypogonadism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 3
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00732 Entrez Gene ID: 2798 OMIM ID: 138850 Swissprot Accession: P30968;