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Description for Protein GNG5

guanine nucleotide binding protein (G protein), gamma 5
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; platelet: 3; undefined: 1)
Summary:
G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04542
KEGG - Pathway(s):
hsa04062
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Guanine nucleotide binding protein G(I)/G(S)/G(O) gamma 5 subunit; G protein gamma 5 subunit; Guanine nucleotide binding protein (G protein), gamma 5
Approved Symbol:
GNG5
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11865 Entrez Gene ID: 2787 OMIM ID: 600874 Swissprot Accession: P63218;