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Description for Protein GNB2

guanine nucleotide binding protein (G protein), beta polypeptide 2
17 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/0)
(membrane: 2; microparticles: 1; platelet: 3)
Summary:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04537
    KEGG - Pathway(s):
    hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanine nucleotide binding protein beta 2; Transducin beta chain 2; G protein beta 2 subunit; Guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 2; Signal transducing guanine nucleotide binding regulatory protein beta subunit
    Approved Symbol:
    GNB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11820 Entrez Gene ID: 2783 OMIM ID: 139390 Swissprot Accession: P62879; Q6FHM2;