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Description for Protein GNAT1

guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 3)
Summary:
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04631
KEGG - Pathway(s):
hsa04744
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Transducin; Rod specific guanine nucleotide binding protein G(T) alpha 1 subunit; Guanine nucleotide binding protein alpha transducing activity polypeptide 1; GBT1; GNATR; Guanine nucleotide binding protein G(T) alpha 1 subunit; Transducin rod specific; G protein alpha transducing 1; Transducin rod specific alpha polypeptide
Approved Symbol:
GNAT1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • B-Octylglucoside(db);
  • Guanosine-5'-Diphosphate(db);
  • Hydroxydimethylarsine Oxide(db);
  • Tetrafluoroaluminate Ion(db)

    Associated Genetic Diseases:

  • Night blindness, congenital stationary, autosomal dominant 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08850 Entrez Gene ID: 2779 OMIM ID: 139330 Swissprot Accession: P11488;