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Description for Protein GNAQ

guanine nucleotide binding protein (G protein), q polypeptide
42 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(alpha granules: 1; membrane: 3; microparticles: 1; platelet: 6; undefined: 1)
Summary:
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04634
    KEGG - Pathway(s):
    hsa04020; hsa04270; hsa04540; hsa04720; hsa04730; hsa04912; hsa04916; hsa04970; hsa05010; hsa05016; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    G alpha q; Guanine nucleotide binding protein Q polypeptide; GAQ
    Approved Symbol:
    GNAQ
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02998 Entrez Gene ID: 2776 OMIM ID: 600998 Swissprot Accession: P50148;