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Description for Protein GMPR

guanosine monophosphate reductase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(microparticles: 1; platelet: 3; secretome: 1)
Summary:
This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.7.1.7
KEGG - Orthology:
K00364
KEGG - Pathway(s):
hsa00230
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GMP reductase; Guanosine 5`-monophosphate oxidoreductase; EC 1.7.1.7
Approved Symbol:
GMPR
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Guanosine-5'-Monophosphate(db)

    Associated Genetic Diseases:

  • GMP reductase polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00754 Entrez Gene ID: 2766 OMIM ID: 139265 Swissprot Accession: P36959;