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Description for Protein AMY1A

amylase, alpha 1A (salivary)
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Aamy_C: Putative GTP-ase activating proteins for the small GTPase, ARF
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.1
    KEGG - Orthology:
    K01176
    KEGG - Pathway(s):
    hsa00500; hsa01100; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AMY1; Amylase, salivary A; Amylase, salivary, alpha-1A; Alpha amylase, salivary; EC 3.2.1.1
    Approved Symbol:
    AMY1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4,6-Dideoxy-4-Amino-Alpha-D-Glucose(db);
  • 4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose(db);
  • 4,6-DIDEOXY-4-{[4-[(4-O-HEXOPYRANOSYLHEXOPYRANOSYL)OXY]-5,6-DIHYDROXY-3-(HYDROXYMETHYL)CYCLOHEX-2-EN-1-YL]AMINO}HEXOPYRANOSYL-(1->4)HEXOPYRANOSYL-(1->4)HEXOPYRANOSE(db);
  • 4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose(db);
  • 4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose(db);
  • 5-Hydroxymethyl-Chonduritol(db);
  • 6-Deoxy-Alpha-D-Glucose(db);
  • Acarbose(db);
  • Acarbose Derived Hexasaccharide(db);
  • Beta-D-Glucose(db);
  • Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam(db);
  • N-[4-Hydroxymethyl-Cyclohexan-6-Yl-1,2,3-Triol]-4,6-Dideoxy-4-Aminoglucopyranoside(db);
  • Pyroglutamic Acid(db);
  • Tris(Hydroxyethyl)Aminomethane(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00096 Entrez Gene ID: 276 OMIM ID: 104700 Swissprot Accession: P04745; Q6NSB3;