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Description for Protein GLUL

glutamate-ammonia ligase
14 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.1.2
KEGG - Orthology:
K01915
KEGG - Pathway(s):
hsa00250; hsa00330; hsa00910; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GLNS; Glutamine synthase; EC 6.3.1.2; GS; Glutamine synthetase
Approved Symbol:
GLUL
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Glutamic Acid(db);
  • L-Glutamine(db)

    Associated Genetic Diseases:

  • Glutamine deficiency, congenital(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00701 Entrez Gene ID: 2752 OMIM ID: 138290 Swissprot Accession: P15104; A8YXX4;