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Description for Protein GLUD1

glutamate dehydrogenase 1
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 1)
Summary:
This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.4.1.3
    KEGG - Orthology:
    K00261
    KEGG - Pathway(s):
    hsa00250; hsa00330; hsa00471; hsa00910; hsa01100; hsa04964
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GDH; GLUD; Glutamate dehydrogenase (NAD(P)+)
    Approved Symbol:
    GLUD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Oxyglutaric Acid(db);
  • Adenosine-5'-Diphosphate(db);
  • Guanosine-5'-Triphosphate(db);
  • Hexachlorophene(db);
  • L-Glutamic Acid(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

  • Hyperinsulinemic hypoglycemia, familial, 6(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11748 Entrez Gene ID: 2746 OMIM ID: 138130 Swissprot Accession: P00367;