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Description for Protein GLO1

glyoxalase I
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 4)
Summary:
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.4.1.5
KEGG - Orthology:
K01759
KEGG - Pathway(s):
hsa00620
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glx1; Lactoylglutathione lyase; Methylglyoxalase; Aldoketomutase; Ketone-aldehyde mutase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5
Approved Symbol:
GLO1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Sulfhydryl-Ethanol(db);
  • Glutathione(db);
  • Indomethacin(db);
  • methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate(db);
  • S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione(db);
  • S-Benzyl-Glutathione(db);
  • S-Hexylglutathione(db);
  • S-P-Nitrobenzyloxycarbonylglutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00730 Entrez Gene ID: 2739 OMIM ID: 138750 Swissprot Accession: Q04760;