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Description for Protein GLDC

glycine dehydrogenase (decarboxylating)
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.4.4.2
KEGG - Orthology:
K00281
KEGG - Pathway(s):
hsa00260; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glycine cleavage system P protein; Glycine dehydrogenase; GCSP; P protein; EC 1.4.4.2; GCE; NKH; HYGN1
Approved Symbol:
GLDC
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; Platelet phosphorylation sites: 2
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glycine(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

  • Glycine encephalopathy(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01996 Entrez Gene ID: 2731 OMIM ID: 238300 Swissprot Accession: P23378;