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Description for Protein HPGDS

hematopoietic prostaglandin D synthase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.3.99.2
KEGG - Orthology:
K01830
KEGG - Pathway(s):
hsa00590; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PGDS; Glutathione requiring prostaglandin D synthase; Glutathione dependent PGD synthetase; Prostaglandin H2 D-isomerase; PTGDS2
Approved Symbol:
HPGDS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID(db);
  • 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride(db);
  • 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid(db);
  • 3-(4-nitrophenyl)-1H-pyrazole(db);
  • 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole(db);
  • 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE(db);
  • 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid(db);
  • Glutathione(db);
  • Glycerol(db);
  • nocodazole(db);
  • PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04001 Entrez Gene ID: 27306 OMIM ID: 602598 Swissprot Accession: O60760;