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Description for Protein GCLM

glutamate-cysteine ligase, modifier subunit
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(platelet: 3; secretome: 1)
Summary:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K11205
KEGG - Pathway(s):
hsa00480; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GLCLR; Glutamate cysteine ligase regulatory subunit; Gamma glutamylcysteine synthetase regulatory subunit; Gamma glutamylcysteine synthetase; Gamma ECS; GCS light chain
Approved Symbol:
GCLM
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Cysteine(db);
  • L-Glutamic Acid(db)

    Associated Genetic Diseases:

  • Myocardial infarction, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03106 Entrez Gene ID: 2730 OMIM ID: 601176 Swissprot Accession: P48507;