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Description for Protein IL1F7

interleukin 1 family, member 7 (zeta)
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IL1: Interleukin-1 homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05485
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Family of interleukin 1 zeta; FIL1 zeta; Interleukin 1 superfamily z; IL 1F7b; FIL1Z; FIL1; IL1Z; IL 1RP1; IL 1H; Interleukin 1 family member 7 isoform 2; IL 1X protein; Interleukin 1 zeta; Interleukin 1 homolog 4; Interleukin 1 related protein; IL 1H4; IL 1 zeta; Interleukin 1 family member 7 isoform 1 proprotein; Interleukin 1 family member 7 isoform 5; Interleukin 1 family member 7 isoform 4; Interleukin 1 family member 7 isoform 3
    Approved Symbol:
    IL1F7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05695 Entrez Gene ID: 27178 OMIM ID: 605510 Swissprot Accession: Q9NZH6;