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Description for Protein GLS2

glutaminase 2 (liver, mitochondrial)
10 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.5.1.2
    KEGG - Orthology:
    K01425
    KEGG - Pathway(s):
    hsa00250; hsa00330; hsa00471; hsa00910; hsa01100; hsa04964
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GA; Liver mitochondrial glutaminase; L glutamine amidohydrolase; Phosphate activated glutaminase; Glutaminase I; LGA; GLS; Glutaminase GA isoform a
    Approved Symbol:
    GLS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Glutamic Acid(db);
  • L-Glutamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05901 Entrez Gene ID: 27165 OMIM ID: 606365 Swissprot Accession: Q9UI32; Q8IX91;