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Description for Protein EIF2AK1

eukaryotic translation initiation factor 2-alpha kinase 1
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08860
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Heme-regulated initiation factor 2-alpha kinase; Heme sensitive initiation factor 2a kinase; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; Heme-controlled repressor; Hemin-sensitive initiation factor-2 alpha kinase; PRO1362; HCR; EC 2.7.1.37; HRI; KIAA1369; Heme-regulated eIF2alpha kinase
    Approved Symbol:
    EIF2AK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10684 Entrez Gene ID: 27102 OMIM ID: - Swissprot Accession: Q9BQI3; Q549K6;