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Description for Protein CACYBP

calcyclin binding protein
15 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 9; secretome: 2)
Summary:
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04507
    KEGG - Pathway(s):
    hsa04310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    SIP; Calcyclin binding protein; CacyBP; PNAS 107; S100A6BP; GIG5; RP1-102G20.6; Growth-inhibiting gene 5 protein; Siah-interacting protein; Calcyclin binding protein isoform 2; Calcyclin binding protein isoform 1; MGC87971
    Approved Symbol:
    CACYBP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07316 Entrez Gene ID: 27101 OMIM ID: 606186 Swissprot Accession: Q9HB71; B3KSF1; Q5R370;