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Description for Protein GK

glycerol kinase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 10)
Summary:
The product of this gene belongs to the FGGY kinase family of proteins and encodes glycerol kinase. Glycerol kinase is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Defects in this gene are the cause of glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.1.30
KEGG - Orthology:
K00864
KEGG - Pathway(s):
hsa00561; hsa01100; hsa03320
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Glycerol kinase isoform a; Glycerol kinase isoform b; ATP glycerol 3-phosphotransferase; Glycerokinase; EC 2.7.1.30
Approved Symbol:
GK
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Glycerol kinase deficiency, isolated(Pd);
  • Hyperglycerolemia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08363 Entrez Gene ID: 2710 OMIM ID: 300474 Swissprot Accession: A6NJP5; Q6IQ27; P32189;