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Description for Protein PPA2

pyrophosphatase (inorganic) 2
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(platelet: 12; undefined: 1)
Summary:
The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.1
    KEGG - Orthology:
    K01507
    KEGG - Pathway(s):
    hsa00190
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Inorganic pyrophosphatase 2 isoform 5; FLJ20459; Inorganic pyrophosphatase 2 isoform 1; Inorganic pyrophosphatase 2 isoform 2; Inorganic pyrophosphatase 2 isoform 3; Inorganic pyrophosphatase 2 isoform 4; HSPC124; MGC49850; SID6-306; Inorganic pyrophosphatase 2, mitochondrial [Precursor]; EC 3.6.1.1; PPase 2; Pyrophosphatase SID6-306
    Approved Symbol:
    PPA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 41
    Human (de-) phosphorylation sites: 41; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18494 Entrez Gene ID: 27068 OMIM ID: 609988 Swissprot Accession: Q9H2U2; A6NKL9;