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Description for Protein LAT

linker for activation of T cells
30 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/2)
(membrane: 2; phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07362
    KEGG - Pathway(s):
    hsa04650; hsa04660; hsa04664; hsa04666
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LAT1; pp36; 36 kDa phospho-tyrosine adaptor protein; Linker for activation of T cells isoform a; Linker for activation of T cells isoform b; Linker for activation of T cells isoform c
    Approved Symbol:
    LAT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 66
    Human (de-) phosphorylation sites: 63; Platelet phosphorylation sites: 8
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03832 Entrez Gene ID: 27040 OMIM ID: 602354 Swissprot Accession: O43561; B7WPI0;