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Description for Protein NOX1

NADPH oxidase 1
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08008
    KEGG - Pathway(s):
    hsa04670
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NOH-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; Mitogenic oxidase 1; MOX1; NADPH oxidase homolog 1; GP91-2; NADPH oxidase 1 isoform long; NADPH oxidase 1 isoform short; NADPH oxidase 1 isoform long variant
    Approved Symbol:
    NOX1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 6
  • Isoform 2 : 3
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 02203 Entrez Gene ID: 27035 OMIM ID: 300225 Swissprot Accession: Q9Y5S8;