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Description for Protein ABL2

v-abl Abelson murine leukemia viral oncogene homolog 2
14 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K08887
    KEGG - Pathway(s):
    hsa04012; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ARG; Oncogene ARG; EC 2.7.1.112; V-abl abelson murine leukemia viral oncogene homolog 2 isoform a
    Approved Symbol:
    ABL2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 180
    Human (de-) phosphorylation sites: 180; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 10
    Human phosphorylation targets: 10; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE(db);
  • Adenosine triphosphate(db);
  • Dasatinib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01259 Entrez Gene ID: 27 OMIM ID: 164690 Swissprot Accession: B7UEF3; P42684; B7UEF4;