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Description for Protein GHRHR

growth hormone releasing hormone receptor
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04584
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Growth hormone releasing factor receptor; GHRFR; GRF receptor; GRFR; Growth hormone releasing hormone receptor isoform b precursor; GHRHRpsv; Growth hormone releasing hormone receptor isoform a precursor
    Approved Symbol:
    GHRHR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sermorelin(db)

    Associated Genetic Diseases:

  • Growth hormone deficiency, isolated(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 3
  • Isoform 1 : 5
    • Additional Identifiers:

    HPRD: 00748 Entrez Gene ID: 2692 OMIM ID: 139191 Swissprot Accession: Q02643; Q16406;