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Description for Protein GGT1

gamma-glutamyltransferase 1
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 20)
Summary:
The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.2.2
    KEGG - Orthology:
    K00681
    KEGG - Pathway(s):
    hsa00430; hsa00450; hsa00460; hsa00480; hsa00590; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GGT; GTG; Gamma glutamyl transferase; Gamma-glutamyl transferase 1; CD224 antigen; Gamma-GT; EC 2.3.2.2; Glutamyl transpeptidase; D22S672; D22S732; MGC96963
    Approved Symbol:
    GGT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 3
  • Isoform 4 : 3
  • Isoform 3 : 3
  • Isoform 2 : 3
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 01980 Entrez Gene ID: 2678 OMIM ID: 612346 Swissprot Accession: P19440;