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Description for Protein GDI1

GDP dissociation inhibitor 1
14 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(membrane: 1; microparticles: 1; platelet: 8; secretome: 1)
Summary:
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
None Available
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
RAB GDP dissociation inhibitor alpha; RABGDIA; RAB GDI alpha; RHOGDI; Oligophrenin 2; OPHN2; MRX41; MRX48; XAP4
Approved Symbol:
GDI1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Geran-8-Yl Geran(db)

    Associated Genetic Diseases:

  • Mental retardation, X-linked 41(Pd);
  • Mental retardation, X-linked 48(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02114 Entrez Gene ID: 2664 OMIM ID: 300104 Swissprot Accession: P31150;