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Description for Protein KAT2A

K(lysine) acetyltransferase 2A
29 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • BROMO: bromo domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.48
    KEGG - Orthology:
    K06062
    KEGG - Pathway(s):
    hsa04330
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GCN5 general control of amino acid synthesis 5 like 2; General control of amino acid synthesis protein 5 like 2; Histone acetyltransferase GCN5; hsGCN5; GCN5; HGCN5
    Approved Symbol:
    KAT2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Coenzyme A(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03807 Entrez Gene ID: 2648 OMIM ID: 602301 Swissprot Accession: Q92830;