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Description for Protein GCK

glucokinase (hexokinase 4)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.2
    KEGG - Orthology:
    K12407
    KEGG - Pathway(s):
    hsa00010; hsa00052; hsa00500; hsa00520; hsa00524; hsa01100; hsa04910; hsa04930; hsa04950
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    GK; GLK; Hexokinase 4; HK4; HXKP; MODY2; EC 2.7.1.1; Hexokinase D, pancreatic isozyme; ATP:D-hexose 6-phosphotransferase; Glucokinase isoform 3; Glucokinase isoform 1; Glucokinase isoform 2
    Approved Symbol:
    GCK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide(db);
  • 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE(db);
  • 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide(db);
  • 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide(db);
  • Beta-D-Glucose(db)

    Associated Genetic Diseases:

  • Diabetes mellitus, gestational(Pd);
  • Diabetes mellitus, noninsulin-dependent, late-onset(Pd);
  • Diabetes mellitus, permanent neonatal(Pd);
  • Hyperinsulinemic hypoglycemia, familial, 3(Pd);
  • Maturity-onset diabetes of the young, type II(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00680 Entrez Gene ID: 2645 OMIM ID: 138079 Swissprot Accession: P35557; Q53Y25;