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Description for Protein GC

group-specific component (vitamin D binding protein)
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(alpha granules: 1; platelet: 1; secretome: 3)
Summary:
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Albumin: serum albumin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12258
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Group specific component; DBP; VDBP; VDBG; Vitamin D binding alpha globulin; GC globulin
    Approved Symbol:
    GC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • GC1/GC2 polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00749 Entrez Gene ID: 2638 OMIM ID: 139200 Swissprot Accession: P02774;