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Description for Protein GAS6

growth arrest-specific 6
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(secretome: 1; undefined: 1)
Summary:
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFL: EGF domain, unclasssified subfamily
  • EGFCA: Calcium-binding EGF-like domain
  • LAMG: Laminin G domain
  • GLA: Domain containing Gla (gamma-carboxyglutamate) residues.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05464
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    AXL receptor tyrosine kinase ligand; AXLLG; AXL stimulatory factor; AXSF
    Approved Symbol:
    GAS6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02705 Entrez Gene ID: 2621 OMIM ID: 600441 Swissprot Accession: B3KRQ7; Q14393; B3KVL4;