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Description for Protein AMD1

adenosylmethionine decarboxylase 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.50
KEGG - Orthology:
K01611
KEGG - Pathway(s):
hsa00270; hsa00330; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
AMD; AdoMetDC; SamDC; DKFZp313L1234; FLJ26964; S-adenosylmethionine decarboxylase proenzyme; EC 4.1.1.50; S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase 1 isoform 1 precursor; S-adenosylmethionine decarboxylase 1 isoform 2
Approved Symbol:
AMD1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5'-{[4-(aminooxy)butyl](methyl)amino}-5'-deoxy-8-ethenyladenosine(db);
  • Hydroxyalanine(db);
  • Putrescine(db);
  • S-Adenosylmethionine(db);
  • Tris(Hydroxymethyl)Aminomethane(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01622 Entrez Gene ID: 262 OMIM ID: 180980 Swissprot Accession: Q5VXN4; P17707;