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Description for Protein GART

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 2)
Summary:
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.1.2.2; 6.3.3.1; 6.3.4.13
KEGG - Orthology:
K11787
KEGG - Pathway(s):
hsa00230; hsa00670; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GARS; PRGS; PAIS; AIRS; PGFT; GARTF; Glycinamide phosphoribosyl transferase; Glycinamide ribonucleotide synthetase; Glycinamide ribonucleotide transformylase; Trifunctional purine biosynthetic protein adenosine-3; EC 6.3.4.13; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase isoform 1; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase isoform 2
Approved Symbol:
GART
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 10-CF3C(OH)2-DDACTHF(db);
  • Glycinamide Ribonucleotide(db);
  • Pemetrexed(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00716 Entrez Gene ID: 2618 OMIM ID: 138440 Swissprot Accession: Q59HH3; P22102;