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Description for Protein GARS

glycyl-tRNA synthetase
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(ATP binding: 1; microparticles: 1; platelet: 1; secretome: 1)
Summary:
This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.1.1.14
    KEGG - Orthology:
    K01880
    KEGG - Pathway(s):
    hsa00970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glycine tRNA ligase; GlyRS; CMT2D; DSMAV; SMAD1; Charcot-Marie-Tooth neuropathy 2D; Charcot-Marie-Tooth neuropathy, neuronal type, D
    Approved Symbol:
    GARS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glycine(db)

    Associated Genetic Diseases:

  • Charcot-Marie-tooth disease, axonal, type 2D(Pd);
  • Neuronopathy, distal hereditary motor, type V(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02617 Entrez Gene ID: 2617 OMIM ID: 600287 Swissprot Accession: P41250;