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Description for Protein WIPI2

WD repeat domain, phosphoinositide interacting 2
9 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CGI50; FLJ12979; FLJ14217; WIPI-2; DKFZP434J154; DKFZp686P02188; FLJ42984; Hypothetical protein LOC26100; WD40 repeat protein interacting with phosphoinositides 2; Hypothetical protein LOC26100 isoform a; Hypothetical protein LOC26100 isoform b; Hypothetical protein LOC26100 isoform d; Atg21; WIPI49 like protein 2; Hypothetical protein LOC26100 isoform c; Hypothetical protein LOC26100 isoform e
    Approved Symbol:
    WIPI2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15679 Entrez Gene ID: 26100 OMIM ID: 609225 Swissprot Accession: Q9Y4P8;