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Description for Protein GGA1

golgi-associated, gamma adaptin ear containing, ARF binding protein 1
24 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 6)
Summary:
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • VHS: Domain present in VPS-27, Hrs and STAM
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12404
    KEGG - Pathway(s):
    hsa04142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Golgi associated gamma adaptin ear containing ARF binding protein 1 isoform 1; Golgi associated gamma adaptin ear containing ARF binding protein 1 isoform 2; Golgi associated gamma adaptin ear containing ARF binding protein 1 isoform 3; Gamma adaptin related protein 1; Golgi associated gamma adaptin ear containing ARF binding protein 1; ADP ribosylation factor binding protein GGA1; ARF binding protein 1
    Approved Symbol:
    GGA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12078 Entrez Gene ID: 26088 OMIM ID: 606004 Swissprot Accession: Q86YA9; Q9UJY5; Q8NCS6;