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Description for Protein APPL1

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
14 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • PTB: Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08733
    KEGG - Pathway(s):
    hsa05200; hsa05210
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DIP13 alpha; Adaptor protein APPL; Signaling adaptor protein DIP13 alpha; Adaptor protein, phosphotyrosine interaction PH domain and leucine zipper containing 1
    Approved Symbol:
    APPL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05053 Entrez Gene ID: 26060 OMIM ID: 604299 Swissprot Accession: Q9UKG1;