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Description for Protein GLCE

glucuronic acid epimerase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; secretome: 1)
Summary:
Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.1.3.17
    KEGG - Orthology:
    K01793
    KEGG - Pathway(s):
    hsa00534; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    KIAA0836; UDP glucuronic acid epimerase; Heparin/heparan sulfate glucuronic acid C5 epimerase; GlcA C5 epimerase; GLCE
    Approved Symbol:
    GLCE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07020 Entrez Gene ID: 26035 OMIM ID: 612134 Swissprot Accession: O94923; B3KML4;