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Description for Protein SH2B1

SH2B adaptor protein 1
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12459
    KEGG - Pathway(s):
    hsa04722
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DKFZP547G1110; KIAA1299; SH2B; FLJ30542; SH2 domain-containing putative adapter SH2-B; SH2-B alpha signaling protein; SH2-B gamma signaling protein; SH2B adaptor protein 1; SH2B1
    Approved Symbol:
    SH2B1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12336 Entrez Gene ID: 25970 OMIM ID: 608937 Swissprot Accession: Q9NRF2; B3KNV5; B4DLN5;