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Description for Protein GAPDH

glyceraldehyde-3-phosphate dehydrogenase
54 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/2)
(alpha granules: 1; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 1; undefined: 1)
Summary:
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.2.1.12
KEGG - Orthology:
K00134
KEGG - Pathway(s):
hsa00010; hsa01100; hsa05010
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
G3PD; EC 1.2.1.12
Approved Symbol:
GAPDH
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 19
Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE(db);
  • Adenosine-5-Diphosphoribose(db);
  • Carboxymethylated Cysteine(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Thionicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00713 Entrez Gene ID: 2597 OMIM ID: 138400 Swissprot Accession: P04406;