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Description for Protein GAP43

growth associated protein 43
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Neuromodulin; Axonal membrane protein GAP-43; Nerve growth related peptide GAP43; Neural phosphoprotein B-50; Neuron growth associated protein 43; Calmodulin binding protein P-57; Phosphoprotein B-50; B-50; PP46
    Approved Symbol:
    GAP43
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01198 Entrez Gene ID: 2596 OMIM ID: 162060 Swissprot Accession: P17677; A8K0Y4; Q5U058;