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Description for Protein MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.4.3
    KEGG - Orthology:
    K13402
    KEGG - Pathway(s):
    hsa00630; hsa00670; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Formyltetrahydrofolate synthetase domain containing 1; DKFZP586G1517; FTHFSDC1; FLJ21145; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Mitochondrial C1-tetrahydrofolate synthetase
    Approved Symbol:
    MTHFD1L
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09967 Entrez Gene ID: 25902 OMIM ID: 611427 Swissprot Accession: Q6UB35;